EBOVAC Laboratory Manager (Sierra Leone) 32 views

We are seeking to appoint a Laboratory Manager to the LSHTM EBOVAC team to be based in Sierra Leone.

The Ebola vaccine projects – EBOVAC1, EBOVAC2 and EBODAC – are a series of trials and associated projects which aim to assess a novel prime-boost preventive vaccine regimen against Ebola Virus Disease (EVD). In a prime-boost vaccine regimen, individuals are first given a dose to prime the immune system, and then a boost dose which is intended to enhance the immune response and increase the duration of the response. The vaccine has been developed by Janssen Vaccines and Prevention B.V. and the trial is funded by the Innovative Medicines Initiative (IMI, a partnership between the EU and the European pharmaceutical industry). Between them, the EBOVAC1 andEBOVAC2 projects will assess – through several clinical trials conducted in phases in Europe and Africa – the safety, tolerability and immunogenicity of the vaccine regimen in response to the urgent public health need raised by the Ebola epidemic.

One of the major trial sites for this work is in Sierra Leone. The post-holder will be based in Kambia district, northern Sierra Leone, with occasional travel to Freetown and will be an integral part of the management team supporting the implementation of the EBOVAC1 and EBOVAC3 vaccine studies. The laboratory has recently expanding to include new studies including a trial of different prophylactic Ebola vaccines and a new study, PREVAC-Up, will start later in 2019. 

The EBOVAC trial site in Kambia has dedicated laboratory facilities, currently staffed with two LSHTM lab scientists and 8 locally recruited lab technicians. In addition, the EBOVAC Laboratory Director is based in Kilifi, Kenya with regular travel to Kambia. The purpose of this Laboratory Manager position is to provide on the ground oversight of lab activities on a day-to-day basis, in order to support the work of the Laboratory Director and to ensure that this new laboratory meets the requirements of the trial sponsor and international standards.

Key responsibilities include:

supporting the Laboratory Director in the management of all laboratory activitiesmanaging LSHTM laboratory staff and locally-employed laboratory personnelensuring all laboratory activities related to the EBOVAC programme and ancillary and future studies are performed in strict accordance to Good Clinical Laboratory Practice (GCLP)ensuring that the laboratory maintains a robust training programmebeing the local focal laboratory contact for trial sponsors, in-country partners and senior LSHTM managementorganising and facilitating laboratory meetings and attending EBOVAC1/3 and related meetingsassisting with communications, including production of laboratory update reports.

The successful applicant will have a higher degree or equivalent professional experience, significant experience of managing an accredited clinical diagnostic laboratory that undertakes clinical trials, practical experience and detailed understanding of implementing regulatory procedures and documentation relating to clinical trials, experience of promoting excellence in areas of laboratory administration and the provision of support services, including the setting of service standards and monitoring of performance, advising on laboratory matters at a senior level, experience of planning laboratory activities for new projects, including budgets, staffing, infrastructure, facilities and equipment. Further particulars are included in the job description.

This full-time post, based in Sierra Leone, is funded by the Innovative Medicines Initiative under the European Commission’s Horizon 2020 Framework Programme until 31 December 2020, and is available immediately. Salary is on the Professional Support Grade 6 scale in the range £39,304 – £44,634 per annum (inclusive of London Weighting). The post will be subject to the LSHTM terms and conditions of service. Annual leave entitlement is 30 working days per year. In addition to this there are discretionary “Director’s Days”. Membership of the Pension Scheme is available.

Applications should be made online via our website at .  The reference for this post is ITD-CRD-2019-08. Online applications will be accepted by the automated system until 10pm on the closing date.  Any queries regarding the application process may be addressed to .

The supporting statement section should set out how your qualifications, experience and training meet each of the selection criteria.  Please provide one or more paragraphs addressing each criterion.The supporting statement is an essential part of the selection process and thus a failure to provide this information will mean that the application will not be considered.  An answer to any of the criteria such as “Please see attached CV” will not be considered acceptable.

Please note that if you are shortlisted and are unable to attend on the interview date it may not be possible to offer you an alternative date.

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